Assessing health-related quality of life in patients with Parkinson's disease in a prospective longitudinal study

Reuther M, Spottke EA, Klotsche J, Riedel O, Peter H, Berger K, Athen O, Köhne-Volland R, Dodel RC.

Parkinsonism Relat Disord. 2007 Mar;13(2):108-14. Epub 2006 Oct 19.
PMID: 17055326

Abstract

Objective:

To prospectively assess the health-related quality of life (HrQoL) in Parkinson's disease (PD) during 12 months..

Methods:

HrQoL was assessed in 145 PD patients using the PD-specific PDQ-39, PDQL and the generic EQ-5D. In addition, clinical rating-scales were used.

Results:

All scales showed a pronounced effect of PD. In comparison to an age-matched population the EQ-5D was considerably affected. In comparison to baseline, however, there was no significant change in the generic scale but a significant change in the sum-score of disease-specific HrQoL-scales.

Results:

Only disease-specific scales were sensitive to change. Further studies are necessary to evaluate the time-dependent change in HrQoL.